Monday, October 27, 2014

All About the Meningococcal Vaccine for Teens: Menactra (MCV4) Meningococcal Vaccine for Teens



In terms of medical history, vaccine for meningitis is relatively new. Meningitis continues to persist as a serious health concern in many parts of the world, including the western hemisphere. Teenagers or others, vaccinated for meningitis as children, may feel that they are safe from this disease. Unfortunately, at this time, that may not be the case.

The current, high incidence of meningitis among teenagers, suggests that those who have had meningitis vaccine previously, may need to have their immunization up-dated, as the level of protection from their original, childhood vaccination may have decreased, in terms of its effectiveness. In other words, there are teenagers who may no longer have proper protection from meningitis.

Teenagers never vaccinated for meningitis, need meningitis vaccine to protect themselves and others from this disease.

Teenagers are particularly vulnerable because of the large numbers who are living together or attending school, high school, college or university. Teens, as well as others, should be aware that the long-term effects suffered by anyone who contacts meningitis are serious and could be life threatening. Re-vaccination or vaccination for meningitis is an appropriate option for teenagers or even their parents to consider at this time.

One of the reasons is that those who were vaccinated between 1974 and 1978 will have only been vaccinated for one subtype of meningitis. There are five subtypes known to exist. Between 1978 and 2005; those vaccinated at that time, will have received the MPSV4 vaccine and not the MCV4 vaccine.

Look at the medical history of meningitis vaccine. In the year 1974, the first vaccine for meningitis licensed for use in the United States, proved to be effective for one of the five, different subtypes of meningococcus. A second meningococcal polysaccharide vaccine, MPSV4, introduced in 1978, covered four of the five subtypes. (1)

Thus, meningococcal vaccine underwent further development.

"A meningococcal conjugate vaccine or "MCV4" (Menactra by sanofi pasteur) was licensed in 2005." (2)

The introduction of this more recent vaccine, Menactra (MCV4), has proven to be more effective for the four subtypes of meningitis. It lasts longer and appears to offer a higher level of immunity or give added protection from the disease. (3)

"The MCV4 vaccine contains Neisseria meningitidis serogroup A, C, Y and W-135 capsular polysaccharide antigens individually conjugated to diphtheria toxoid protein. The vaccine does not contain live bacteria." (4)

Those vaccinated with MCV4, receive immunization against meningitis subtypes A, C. Y and W-135, but not subtype B. MCV4 does not offer protection for the subtype B. There is no vaccine for subtype B.

Teenagers or others, including those vaccinated for meningitis as children, may now be vulnerable to possible meningitis infection. The disease can spread to others. Thus, there is an urgent need for the majority of teenagers to be re-vaccinated or at least to have their original vaccination with the MCV4 vaccine.

What is meningitis and why is it such a serious concern for teenagers?

"Meningitis is an inflammation of the membranes that cover the brain and spinal cord. People sometimes refer to it as spinal meningitis. Meningitis is caused by a viral or bacterial infection. Knowing whether meningitis is caused by a virus or bacterium is important because the severity of illness and the treatment differ depending on the cause. Viral meningitis is less severe and clears up without specific treatment. But bacterial meningitis can be quite severe and may result in brain damage, hearing loss, or learning disabilities." (5)

MCV4 meningitis vaccine protects a person against bacterial meningitis, but not viral meningitis.

The method of immunization is injection into the muscles. Normally, only one dosage of MCV4 is required. 

There are some instances when repeated dosages are given. This immunization is currently recommended for teenagers, who are eleven to eighteen years of age. This vaccine is not recommended for children under the age of two years or for adults who are over the age of fifty-five. (6)

Redness, pain at the injection site or fever lasting one to two days, are the possible side effects experienced by approximately half of those who receive the vaccine. Allergic reactions to this vaccine appear to be rare. 

There has been a low incidence of Guillain-Barre syndrome, reported after vaccination, but there have not been enough cases to attribute this to the administration of the vaccine. MCV4 is not recommended for those with this medical condition, patients who are moderately to severely ill or anyone who has experienced previous allergic reactions to meningococcal vaccines. (7)

All teenagers should ask their doctors about the MCV4 vaccine. Others, who should contact their doctors about being vaccinated or re-vaccinated with MCV4 vaccine, include the following: college freshmen living in dormitories, individuals who have a damaged or missing spleen; persons with an immune deficiency disorder, persons working with meningococcus bacteria in laboratories, travelers to sub-Saharan Africa or other countries where this vaccine is recommended, US military recruits, anyone exposed to an outbreak of meningitis (8)

For teenagers or others, who have concerns or questions about their current level of protection from meningitis, it may be a good time to make a serious inquiry about meningitis immunization or re-immunization with the MCV4 vaccine. Your health and that of others may depend on it.


2. Ibid.

3. Ibid.

4. Ibid.


6. Op. Cit. qandavax.asp

7. Ibid.

8. Ibid.


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